The Lymphatics and the Inflammatory Response: Lessons Learned from Human Lymphedema
Identifieur interne : 003093 ( Main/Exploration ); précédent : 003092; suivant : 003094The Lymphatics and the Inflammatory Response: Lessons Learned from Human Lymphedema
Auteurs : Stanley G. RocksonSource :
- Lymphatic Research and Biology [ 1539-6851 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Humains, Inflammation (anatomopathologie), Inflammation (génétique), Inflammation (physiopathologie), Lymphoedème (anatomopathologie), Lymphoedème (génétique), Lymphoedème (physiopathologie), Modèles animaux de maladie humaine, Prédisposition génétique à une maladie (génétique), RT-PCR, Réseaux de régulation génique, Souris, Système lymphatique (anatomopathologie), Système lymphatique (métabolisme), Système lymphatique (physiopathologie), Séquençage par oligonucléotides en batterie, Transcriptome.
- MESH :
- anatomopathologie : Inflammation, Lymphoedème, Système lymphatique.
- génétique : Inflammation, Lymphoedème, Prédisposition génétique à une maladie.
- métabolisme : Système lymphatique.
- physiopathologie : Inflammation, Lymphoedème, Système lymphatique.
- Animaux, Humains, Modèles animaux de maladie humaine, RT-PCR, Réseaux de régulation génique, Souris, Séquençage par oligonucléotides en batterie, Transcriptome.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Gene Regulatory Networks, Genetic Predisposition to Disease (genetics), Humans, Inflammation (genetics), Inflammation (pathology), Inflammation (physiopathology), Lymphatic System (metabolism), Lymphatic System (pathology), Lymphatic System (physiopathology), Lymphedema (genetics), Lymphedema (pathology), Lymphedema (physiopathology), Mice, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Transcriptome.
- MESH :
- genetics : Genetic Predisposition to Disease, Inflammation, Lymphedema.
- metabolism : Lymphatic System.
- pathology : Inflammation, Lymphatic System, Lymphedema.
- physiopathology : Inflammation, Lymphatic System, Lymphedema.
- Animals, Disease Models, Animal, Gene Regulatory Networks, Humans, Mice, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Transcriptome.
Abstract
In lymphedema, there is a profound predisposition to infection with bacterial pathogens. It therefore seems appropriate to reconsider our unique functional definition of the lymphatic structures within a circulatory construct. While the lymphatics unquestionably fulfill a vital circulatory function, it seems more appropriate to view this complex network, comprised both of endothelial-lined vessels and of lymphoid tissue, as the nexus between the circulatory and immune systems. Viewed in this fashion, it becomes evident that the complex biology of regional lymphatic disruption is a manifestation of the interplay between these two vital bodily functions.
Experimental lymph stasis in murine model has been utilized to effectively demonstrate the pathological attributes of human lymphedema, namely, inflammation, fat deposition, and fibrosis. Large-scale transcriptional corroborates the role of inflammatory mechanisms. The murine studies have set the stage for subsequent translational investigation of human lymphedema. Many of the gene expression pathways invoked by lymphedema are relevant to the inflammatory response and have provided a pragmatic approach to the successful identification of potentially relevant circulating biomarkers for human lymphedema.
Url:
DOI: 10.1089/lrb.2013.1132
PubMed: 24024576
PubMed Central: 3780325
Affiliations:
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Le document en format XML
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It therefore seems appropriate to reconsider our unique functional definition of the lymphatic structures within a circulatory construct. While the lymphatics unquestionably fulfill a vital circulatory function, it seems more appropriate to view this complex network, comprised both of endothelial-lined vessels and of lymphoid tissue, as the nexus between the circulatory and immune systems. Viewed in this fashion, it becomes evident that the complex biology of regional lymphatic disruption is a manifestation of the interplay between these two vital bodily functions.</p><p>Experimental lymph stasis in murine model has been utilized to effectively demonstrate the pathological attributes of human lymphedema, namely, inflammation, fat deposition, and fibrosis. Large-scale transcriptional corroborates the role of inflammatory mechanisms. The murine studies have set the stage for subsequent translational investigation of human lymphedema. Many of the gene expression pathways invoked by lymphedema are relevant to the inflammatory response and have provided a pragmatic approach to the successful identification of potentially relevant circulating biomarkers for human lymphedema.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Rockson, Stanley G" sort="Rockson, Stanley G" uniqKey="Rockson S" first="Stanley G." last="Rockson">Stanley G. Rockson</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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